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1 It is a burden on individuals, communities and economies, causing various diseases and preventable deaths

SSR591813, a novel selective and partial alpha4beta2 nicotinic receptor agonist with potential as an aid to smoking cessation

The proposed claimthat using ZYN instead of cigarettes places users at lower risk of mouth cancer, heart disease, lung cancer, stroke, emphysema, and chronic bronchitisdirectly addresses the comparative harm profile that is central to the MRTP frameworks public health goals