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Development of tolerance, requiring more nicotine to achieve the same effects

To date, there are no published trials evaluating its use in this population

European Neuropsychopharmacology

Since tobacco smoking is driven primarily by addiction to nicotine, but the harm from smoking is caused by other smoke constituents, the rational next-best option is to reduce the harm arising from nicotine use by providing it in a form that does not involve inhaling smoke, the report said.

Pickup Measurements: Neck - 0.83" 12th - 0.89"

"Early signs of heart disease and stroke are found in young people who smoke," the report said