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Definition and index calculation In this study, prenatal first-hand smoke exposure (FHS) was defined as a mother who smoked at least one cigarette each day for over 6 months before and during pregnancy [18, 19], and the prenatal second-hand smoke exposure (SHS) was defined as a non-smoking women who exposed to cigarette smoke for at least 10 min each day during pregnancy [22]

Industry Concerns Over Cost and Uncertainty: Small manufacturers said multi-session PK studies can cost millions of dollars and argued that the absence of defined numeric thresholds creates financial risk and regulatory unpredictability

Studies have demonstrated that the risk of developing CKD is significantly greater for smokers than for non-smokers

Food and Drug Administration (FDA) proposed new national program standards that would ban the production and sale of menthol cigarettes

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