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doi: 10.1007/s00406-012-0339-2 13 MoranPStewartRBrughaTBebbingtonPBhugraDJenkinsRet al

The smoldering speed of the cigarette is moderate, which indicates that the tobacco has minimal trash content and there is simply no chemistry as such

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Smoking also induces ROS production by leukocytes and enhances leukocyte transmigration by increasing the expression of adhesion molecules (ICAM-1, VCAM-1, and E-selectin) and triggering NF-kB transcription, shifting the endothelial phenotype from an anti-thrombotic to a pro-thrombotic and pro-inflammatory state [24,25,26,27,28]