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Description
Similarly, 5-methylcytosine (5 mC) is directly oxidized to 5-hydroxymethylcytosine (5-hmC), rendering it unrecognizable by DNA methyltransferases and leading to changes in the overall methylation pattern

doi: 10.1152/ajpgi.00079.2004 28 JiangX.WuJ.WangJ.HuangR
This significant increase in pneumonia hospitalization risk in the increasers was consistently found regardless of smoking amount and pack-years of smoking (Table 2)

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Easy on fans and blowers

The flavour lasts a long time, and the nicotine hit is smooth but strong
