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In patients with diabetes, any alcohol intake may reduce their ability to control blood glucose levels adequately and contribute to diabetes-associated cardiovascular and neurologic complications

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10.1371/journal.pmed.1000058 Office of the Surgeon General (US), Office on Smoking and Health (US): The Health Consequences of Smoking: A Report of the Surgeon General

The problem is that the brain starts to rely on nicotine to stimulate these pathways and failing to re-dose leaves the brain without, leading to nicotine withdrawal symptoms

In the 90's he decided he'd like to learn to fly and get his private pilots licence