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Also, overexpression of heme oxygenase-1, a stress-induced enzyme that produces endogenous carbon monoxide, has been found to protect dopaminergic neurons from neurotoxicity in an animal model of Parkinsons. In addition, nicotine, a major constituent of cigarette smoke, has been found to be ineffective at slowing the diseases progression in a recently reported clinical trial

Kim, J.-H

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Results show that, among ex-smokers who had quit five or more years prior to the study, those who had gone on to use e-cigarettes were more likely to die from lung cancer (adjusted HR=2.69, 95%CI 1.126.46) than those who had not