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Nicotine withdrawal drives relapse Upon inhalation of cigarette smoke, nicotine enters the blood stream, crosses the bloodbrain barrier and binds to nicotinic receptors in the midbrain thereby increasing the release of neurotransmitters such as dopamine, which is responsible for the rewarding and addictive effects of nicotine

The pungent smell of a cigarette let me know she was nearby, and even though she was emotionally unavailable, she was still around, puffing out her problems, and trying to master the day

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Regarding long-term effects, Moheimani et al

Both smokers and innocent passive smokers develop health issues like cancer, heart disease, respiratory and digestive problems