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Menthol fundamentally alters nicotine receptors, masks the adverse sensory properties of tobacco products (which ultimately may enhance nicotine intake and drive relapse), and alters nicotine metabolism, increasing its bioavailability, according to a 2020 review published in Nicotine & Tobacco Research Adolescent menthol smokers show significantly higher levels of nicotine dependence, tolerance and emotional attachment to cigarettes, compared to non-menthol smoking peers, according to a 2020 study

These pollutants will cause many effects such as toxicity and genetic change in urban organisms 35,36,37

More importantly, mutp53 can co-aggregate with p63 and p73, preventing p63 and p73 from entering the nucleus to perform transcriptional regulatory functions [37]