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The carcinogens present in tobacco smoke can cause irreparable damage to cellular DNA, leading to the uncontrolled growth of cancerous cells

Samples were normalized by calculating the FPKM-UQ values and then log transformed as log2 (X + 0.01) for statistical analysis, except for single sample gene set enrichment analysis (ssGSEA) which was performed on data in linear space using the Broad Institutes Gene Pattern website platform

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They regarded the market as the "First Workshop"meaning raw materials were subject to production needs, production was subject to market demands, and everything served the market