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For those who have term insurance policies, disclosing their new smoking habit will be mandatory for policy renewal

It also has been shown that nicotine exposure decreases the total cell number and number of cell projections in specific areas of the brain, with the caudate affected most severely

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Dysregulation of estrogen metabolism due to CC-smoke exposure have been detected via upregulation of a key cytochrome P450 gene that can metabolize estrogens such as beta-estradiol to potentially carcinogenic catechol and quinine forms 67

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