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Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Archived from the original on December 29, 2019

It has been reported that mutant p53 protein can negatively impact the cytotoxic effects of cisplatin treatment for NSCLC via the upregulation of NRF2, a transcription factor that was reported to contribute to the resistance of malignant cells to several anti-cancer drugs [205]

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Gambogic acid counteracts mutant p53 stability by inducing autophagy

In addition to regulating inflammatory factors, DNMT1 can also be activated by inflammatory factors, such as IL - 6 , transforming growth factor beta 1 [117] and IL - 1 [118]