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5-7, 10 Because of the way this medication mimics the presence of nicotine and attaches to the nicotinic acetylcholine receptors in the brain, it is not designed to be used in combination with nicotine replacement therapy unless directed otherwise by a health care provider

Research is ongoing in this area, in the form of a national multi-centre clinical trial funded by the National Institute for Health and Social Care Research (NIHR)

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However, those who formerly smoked had the greatest consensus, with 97.2% ranking no tobacco as least harmful, compared to 85.2% of those intending to quit smoking and 87.2% of those not intending to quit

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This study was performed to determine the contents of some major toxic components in the mainstream smoke of herbal cigarette A and to evaluate the mutagenicity of smoke condensates and compare them with the corresponding values of general cigarette T with the same tar level