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Attitude Vapes did not respond to the ASA's inquiries and was told it must do so "in future"

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4.3 Cellular and molecular mechanisms 4.3.1 Animal studies 4.3.1.1 Spontaneous colitis and periodontal breakdown (natural history of the disease) Spontaneous periodontal breakdown has also been observed in chemically induced and genetically based animal models of IBD

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Neither varenicline nor nicotine replacement had been shown to decrease drinking rates in smokers before, so it was unclear why the study participants reduced their drinking during the study

The sample was predominantly White Scottish across all groups, though this proportion was highest among current e-cigarette users (84.0%) and dual users (84.4%) and lowest among never users (74.2%), who had the greatest ethnic diversity