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Incapsula incident ID: 269000700259164282-193063354113003915

Britten is highly concerned about his patients who smoke

The available data suggest that p53 mutations in lung cancers can be attributed to direct DNA damage from cigarette smoke carcinogens rather than to selection of pre-existing endogenous mutations

2007 Apr;8:2923

Similar results were observed in other NSCLC mouse models containing LSL-Kras G12D and p53ER TAM alleles, whereby p53 can be switched between the knockout and the WT state by tamoxifen administration [154]

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