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Throughout the colonial period commercial production of tobacco had centered in Northern port cities, but by the antebellum period, as a result of a surplus of slave labor and the great supply of raw material, commercial manufacturing shifted to the tobacco-growing regions in the South

As BMI, after age, was one of the main factors of increased risk of hypertension 36 , the absence of added effects of tobacco use on alcohol consumption observed could be explained by these inverse interactions with BMI

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