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Introduction: This study investigated the risks for all-cause death and death from cancer or cardiovascular diseases due to smoking status and behavior, focusing on differences in smoking duration and amount stratified by sex

Injection-site reactions and worsening of pre-existing diabetic retinopathy are also relevant clinical concerns

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We suggest against using e-cigarettes for smoking cessation for most people because of uncertainty about unapproved products, long-term harms, and public health impacts, but recognize that this may be considered for people who have unsuccessfully attempted other interventions or express a strong preference.Interpretation:This guideline provides a menu of evidence-based options to support smoking cessation