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In general, acute UVR exposures result in extensive DNA lesions, which trigger DNA damage response pathways

The study was ratified by Institutional Review Board of Central South University, implemented in keeping with EU Directive 2010/63/EU

Consistent with this finding, previous studies reported the degree of DNA damage correlated with the exposure of HBE cells to increasing concentrations of CSE 17

In these mice aggressive neuroendocrine lung tumours can be induced upon intra-nasal or intra-tracheal delivery of Adeno-Cre viruses [145]

Similar results were observed in other NSCLC mouse models containing LSL-Kras G12D and p53ER TAM alleles, whereby p53 can be switched between the knockout and the WT state by tamoxifen administration [154]