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COVID19nAChRsCNS It is of interest to note that SARSCoV2 may enter the central nervous system (CNS) through the bloodstream, via the olfactory nerve across the cribriform plate, by disrupting the bloodbrain barrier (BBB) or infecting the peripheral nerves [43, 67, 68, 69], where it may cause ACE2 downregulation and a local inflammatory response referred to as neuroinvasion, a common feature of coronaviruses [70]

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The olfactory epithelium, which sits directly behind the nasal mucosa and is responsible for your sense of smell, is in close proximity to the inhaled aerosol with every draw, making this tissue system particularly vulnerable to irritation

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