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Statistical analysis Given the limited availability of literature pertaining to individuals that use DIY e-cigarette liquid methods, we applied principles of Grounded Theory to guide our content analysis 32

10.4049/jimmunol.1101567 51 SmithC

Next, we step-wisely removed potential pleiotropic SNPs from the above PRSs to obtain the valid-PRSs, again based on a pre-defined set of P -value thresholds for the exploratory GWAS (i.e., 0.05, 0.1, 0.2, 0.3, 0.4, and 0.5)