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Keywords: cigarette smoking, gastrointestinal inflammation, inflammatory bowel disease, ulcerative colitis, Crohns disease Introduction Cigarette smoking is a major risk factor for the development of vascular diseases, such as atherosclerosis and pulmonary hypertension (1)

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Similarly, ex-smokers who quit smoking less than five years earlier, and who used e-cigarettes, were found to have a higher risk of lung cancer (adjusted HR=1.26, 95%CI 1.031.54)

Cigarette Smoke Extract (CSE) Delays NOD2 Expression and Affects NOD2/RIPK2 Interactions in Intestinal Epithelial Cells