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When talking about nicotine, theres a range when comparing to cigarettes because people smoke cigarettes differently, so people are exposed to different amounts of nicotine per cigarette, McGee said

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Grahams letter explains that he had attended a regional symposium on addictions, during which he had learned that the harms of smoking are almost entirely resident in the smoke, while nicotine is relatively harmless.[26] Therefore, he suggested, it should not be beyond the wit of man to separate nicotine addiction from carcinogenesis

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