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Knudsens work found that liraglutide was internalized by proopiomelanocortin (POMC)/cocaine- and amphetamine-regulated transcript (CART) neurons and indirectly inhibits neuropeptide Y (NPY) and agouti-related peptide (AgRP) neurons through Gamma Amino Butyric Acid (GABA) dependent signaling

doi: 10.1038/icb.2008.62 5 KorneteMMasonESPiccirilloCA

[PubMed] [Google Scholar] Elbrond B

Managing side effects is a common reason people look for supplements alongside their GLP-1 medications

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Similarly, in the SURMOUNT-1 trial, all participants received lifestyle intervention which included regular counseling with a dietitian or qualified health professional to achieve a 500 kcal/day energy deficit and 150 minutes of physical activity weekly