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Therefore, melatonin appears to be an important factor supporting neuroprotection in Alzheimers disease, through multidirectional modulation of cholinergic system function, which may be crucial for alleviating cognitive symptoms in patients with AD

The article also notes that transcription factors, like NF-B and AP-1, which control inflammatory and apoptotic responses in cochlear cells, can be activated by hydrogen peroxide (H 2 O 2 ), a reactive oxygen species [34]

The combination of adherent exercise and Lira treatment reduced abdominal obesity and may therefore reduce obesity risk more than the individual treatments [101]

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