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It has been shown that TMAO causes an increase in electrical remodeling and inflammation of the ganglionated plexi, which speeds up the course of arrhythmias such as AF

TMAO has a high turnover rate, with more than 90% excreted in the urine after being metabolized by the kidney ( Figure 1 Studies have found that high levels of TMAO are closely related to the occurrence of atherosclerosis, HF, hypertension, and other CVDs ( Figure 2 )

[DOI] [PMC free article] [PubMed] [Google Scholar] 280.Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, et al

Emerging links between the biological clock and the DNA damage response

10.1128/EC.00216-06 10 BoardP

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