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Furthermore, wheat germ oil has been shown to significantly reduce lipid peroxidation levels in testicular tissues and improve antioxidant defenses to protect against sertraline-induced testicular damage ( Sertraline was shown to impair both the ligand-induced acrosome reaction and spermatozoa entry into viscous media and it almost completely inhibited the sperm-specific Ca 2+ -permeable ion channel (CatSper), with a significant inhibitory effect on prostaglandin-induced Ca 2+ influx (Figure 1)

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This is consistent with a prior study, where IP administered CoQ 10 was primarily localized to the soluble cytosolic fraction of liver cells and was recovered as the oxidized form, not the reduced form [183]