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Similarly, experiments combining ICB and ACT immunotherapies and a TME-activated glutamine antagonist demonstrated improved responses in mouse models of melanoma, lymphoma, and colon cancer (139)

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Beneficial effects of mercaptoethylguanidine, an inhibitor of the inducible isoform of nitric oxide synthase and a scavenger of peroxynitrite, in a porcine model of delayed hemorrhagic shock

Its effects were also associated with the regulation of ATGL, GLUT4, PPAR, PPAR, NO, Ca 2+ , and MDA levels

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Inhibition of cholesterol esterification in T cells by genetic ablation or pharmacological inhibition of ACAT1 (a key cholesterol esterase) can lead to potentiated effector function and enhanced proliferation of CD8(+) T cells by increasing plasma membrane cholesterol levels, which causes enhanced T-cell receptor clustering and signaling as well as more efficient formation of the immunological synapse, thereby controlling the growth and metastasis of mouse melanoma (284)