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Like erythropoietin, most of the growth factors isolated have been glycoproteins, are very active in vivo, and in vitro interact with their target cells via specific cell surface receptors, and ultimately (via intracellular signals) affect gene expression, thereby promoting differentiation

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Trends Pharmacol Sci 27(9):458460 Saleem S, Shah ZA, Urade Y, Dor S (2009) Lipocalin-prostaglandin D synthase is a critical beneficial factor in transient and permanent focal cerebral ischemia

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