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Also, 500mg per day is an effective dose but up to 2,000 mg has been shown to have additional benefits

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Glutathione plays an important role in the theory of aging that cumulative oxidative stress in mitochondria may determine lifespan

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In addition to the activity of the two enzymes involved in GSH synthesis, the availability of the amino acid substrates for GSH synthesis determines the rate of GSH synthesis and the GSH concentration in cultured rat astrocytes (Dringen and Hamprecht 1998