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van Mil NH, Oosterbaan AM, Steegers-Theunissen RPM

Both variants had not previously been described and were classified as pathogenic according to the American College of Medical Genetics (ACMG) guidelines [13]

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Follistatin and androgen suppression in the ovary Follistatin is an endogenous glycoprotein that binds and neutralizes activin, a TGF- family member that regulates FSH secretion and granulosa cell differentiation

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It could also be a symptom of Adrenal Fatigue (AF), which is caused by chronic stress and results in the overuse of the NeuroEndoMetabolic (NEM) stress response, keeping cortisol levels high
