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Subjects were treated with open-label VYVANSE for at least 26 weeks prior to being assessed for entry into the randomized withdrawal period

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Furthermore, the serum BHB level may vary depending on the time of day as BHB tends to be lower in the morning

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FIGURE 5 Age- and sex-dependent effects of pomegranate extract on TMAO response Although the overall effect of the pomegranate extract on plasma TMAO AUC was null ( P = 0.945), we observed that the participants with increasing TMAO were older (Figure 6A), and in particular the three oldest women ( n = 3