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Broad reviews converge on T4s roles in repair/regeneration and inflammation control, which is why TB-500 is often positioned for whole-tissue recovery rather than a single tissue type
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In the context of cancer, multiple clinical trials using CQ or HCQ either in combination or as monotherapy are currently in progress showing partly promising results in terms of anticancer effects and toxicity in early phase studies

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However, it is not known whether vitamin B 12 supplementation, in addition to folic acid supplementation, may be beneficial in the prevention of NTD (62) randomized controlled trials are needed to address this question

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