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murine macrophages exposed to swollen conidia of the fungal pathogen ( mitoROS production increases compared to untreated macrophages or those treated with resting conidia [91]

In the liver, glutathione S-transferase enzymes conjugate GSH to reactive metabolites and toxins, making them water-soluble for excretion a process central to Phase II detoxification

found that dietary Gln supplementation can elevate Gln levels in the TME, decrease the expression of immunosuppressive genes such as Ctla4 and Nrp1 in Tregs, inhibit Treg differentiation, and consequently enhance the tumor immune response (52)

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