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In this respect, a recent review by Cairney and McConkey [277] emphasizes the potential role of Toxoplasma -induced norepinephrine suppression in mediating neuropsychiatric disorders and cognitive impairments, pointing to norepinephrine dysregulation as one of the likely mechanisms

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Hence, the most appropriate antagonist would be a compound that exhibits inhibitory activity in the low micromolar range, thus preserving the physiological function of the receptors while inhibiting them when overactivated

8 A 12-week Phase 2 study generated optimistic results and press coverage, with an early report suggesting that participants on the best-performing dose lost meaningfully more weight than placebo the sort of signal that justifies advancing a candidate

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