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Some research has shown that even in the absence of functional beta-3 receptors, acute AOD-9604 administration still increased energy expenditure and fat oxidation, suggesting the peptide may influence brown fat or thermogenic pathways through additional mechanisms

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However, the large number of significant correlations noted in this study between Parasutterella relative abundance and EWAT metabolites strongly supports the relevance of this genus to the EWAT metabolome

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