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Cancer patients produce many inflammatory cytokines [8, 9], such as tumor necrosis factor-alpha (TNF-) [10, 11], proteolysis-inducing factor (PIF), interleukin-1 (IL-1) [9, 12], and interleukin-6 (IL-6) [8, 13]

All animal experimentation was conducted in accordance with the regulations of Islamic Azad University, Animal Ethics Committee

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The density indicates some flexibility at R471 in both the inward-facing and ipratropium-bound structures, but both are pointing down towards the extracellular side and wedged between S157 and S467, preventing the H-bond network we observe in the occluded conformation (Fig

Previous studies have proposed a variety of mechanisms of LAC in the treatment of depression

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