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Description
Aberrant aggregation of misfolded or denatured proteins has been observed in many diseases, such as cardiovascular disease, metabolic syndrome, cancer, and neurodegenerative disease [95]
18 Thus, the design of lipid-based nanosystems should consider the formulation and the device as a single entity
3-MST then catalyzes the conversion of 3-mercaptopyruvate to pyruvate and H 2 S (4, 5) in the presence of reducing agents such as thioredoxin or dihydrolipoic acid (6)
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TB-500's mechanism is actin-binding it binds G-actin and modulates cytoskeletal dynamics in a way that promotes cell migration and tissue remodelling
Daumke O, Weyand M, Chakrabarti PP, Vetter IR, Wittinghofer A
