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By doing this he was able to 'refigure cells of the immune system as a Darwinian microcosm' (Anderson, Mackay)

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Koechling UM, Amit Z

This condition is often linked to lifestyle factors such as poor diet, obesity, and excessive alcohol consumption

References: National Center for Biotechnology Information (2023)

In terms of mechanism, the implicated drug is believed to interact with its specific HLA to form a hapten-HLA complex, which is then presented to T nave cells (TH0), via a T-Cell Receptor (TCR) to stimulate an immune response.19 It is important to highlight that the associations between the risk of a given drug and a specific HLA have a high negative predictive value and moderate to low Positive Predictive Values (PPV)