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Aberrant histone methylation and acetylation, ATRX mutations impacting chromatin stability, and widespread promoter hypermethylation, including MGMT, disrupt the balance between tumor suppressor genes and oncogenic pathways
Singapore medical journal
These transcriptional changes create a self-amplifying cycle of ROS accumulation and mitochondrial decline [47, 48]
Smoking: This introduces massive amounts of oxidative stress
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Recent advances in tumor microenvironment hydrogen peroxide-responsive materials for cancer photodynamic therapy
