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Consistent with these findings, vitamin C decreased glucose consumption, lactate and ATP production in HCT116 cells [43]

Differential regulation of gamma-glutamylcysteine synthetase heavy and light subunit gene expression

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However, there are still a lot of questions that remain to be answered about the relationship between folate levels in the colonic mucosa and the systemic circulation and the colorectal cancer risk, and about the role of folate derived from the diet and that from local microbial production 287,288,289,290

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11 , e0163600, doi:10.1371/journal.pone.0163600 (2016)