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By contrary, reduced glutathione as well as antioxidant enzyme activities, were decreased

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Although the inhibitory effect of erastin towards system xc is well-documented, nothing is known about its mechanism of action

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As a consequence, exposure of human spermatozoa to intrinsically- or extrinsically- generated reactive oxygen intermediates can result in a state of oxidative stress characterized by peroxidative damage to the sperm plasma membrane and DNA damage to the mitochondrial and nuclear genomes