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Low nanomolar concentrations of PregS induce a delayed onset increase of the neuronal response to NMDA and trafficking of NMDAR to the cell surface through an intracellular Ca 2+ ([Ca 2+ ]i)-dependent and non-canonical mechanism involving G-proteins (47) (Figure 2)

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Group A subjects were exposed to a 90 dB HL 3 kHz pure tone for 10 min