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Immune checkpoint inhibitor therapy induces inflammatory activity in large arteries

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Uncontrolled peroxidation of PUFA-PLs is identified as the crucial downstream mechanism that it may damage membrane and lead to the pore formation, comprising the integrity of membrane

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EVs can be classified as large or small according to their size, with a breakpoint at 5 mm in diameter [32], or they can be classified as F1 (linearly dilated, small and straight varices), F2 (beady varices, tortuous and occupying less than one third of the esophageal lumen), or F3(nodular varices, large and occupying more than one third of the esophageal lumen) [33]