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However, IL-15-mediated upregulation of ZO-1 and ZO-2 expression was independent of the IL-2R subunit, whereas phosphorylation of occludin and enhanced membrane association of claudin-1 and claudin-2 by IL-15 required the presence of the IL-2R subunit

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Initiation of pharmacotherapy When appropriate, hepatologists should initiate first-line pharmacologic treatments such as nicotine replacement therapy (NRT), varenicline, or bupropion, all of which have proven efficacy in smoking cessation

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PubMed PMID: 11189447

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