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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

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Reduction Sodium borohydride reduction of an aldose makes the ends of the resulting alditol chain identical, HOCH 2 (CHOH) n CH 2 OH, thereby accomplishing the same configurational change produced by oxidation to an aldaric acid

Mechanistically, choline and methionine relate to hepatic fat transport and one-carbon metabolism