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Geetika Srivastava (MD, AIIMS)
Neccrostatin-1 (Nec-1), the necroptosis inhibitor by targeting RIPK1, can inhibit RPE cell death by inhibiting both lipid ROS accumulation, providing further evidence that lipid peroxidation drives the occurrence of necroptosis [73]
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Accessed November 30, 2025
PSMF1/PI31 can bind to the 20S catalytic molecule of the 26S proteasome, making it difficult for the substrate to access the enzyme core and thus inhibiting the activity of the proteasomes [50]
