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Preclinical studies should systematically evaluate combination efficacy, optimal sequencing, and mechanisms of synergy

Mtr expression was similar between genotypes on the restricted and low (0.43%) MET diets but much higher in liver from dwarf animals consuming the MET-enriched food (Figure 2, Additional file 2)

For clinical translation, we propose stratifying LUSC patients based on Np63/SSP enzyme expression to identify candidates for serine metabolism-targeted therapy

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Plasma albumin redox state was shifted to a more oxidized state in rats fed 3% casein (CN) diet than those fed 3% whey protein or 3% wheat gluten diet, while supplementing 3% CN diet with cystine reversed it to a more reduced state, indicating that cystine would complement the shortage of cysteine in CN, thereby increasing albumin synthesis rate

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