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The intensity of mTORC1 signaling appears to have consequences on differentiation

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However, simultaneous inhibition of GPX4 and DHODH abolishes this protective capacity, resulting in profound mitochondrial lipid peroxidation and extensive ferroptotic cell death

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Pfam and SMART programs were used to detect candidate genes that may contain GST domains obtained from the BLASTP and HMMER 3.0 analysis results

Blood Hemogram, Smear, Iron studies, Ceruloplasmin, Copper studies, Eye exam were normal