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Currently, clinical trials are investigating efficacy of CB-839 treatment in AML (NCT02071927) ( 5 Conclusions Considering our results and those of previous studies, we suggest that CLL cells can efficiently rewire their amino-acid and glucose metabolism to evade glutaminase inhibition

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[DOI] [PMC free article] [PubMed] [Google Scholar] 134.Stan SD, Singh SV, Whitcomb DC, Brand RE

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4 In addition, central nervous system (CNS) disturbances have been reported in up to 11% of patients receiving HD-MTX therapy