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In brain OHB can be produced in astrocytes from oxidation of fatty acids or catabolism of amino acids and is metabolised in the mitochondria of all brain cell types although uptake across the blood brain barrier is a metabolic control point

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Human clinical trials establishing these effects have not been completed and conclusions about efficacy in humans should not be drawn from this data alone

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Blood examination showed an elevated estradiol level as high as 3482pg/ml

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